- Sam & Max: Freelance Police
- Samantha Who?
- Same Name
- Samurai 7
- Samurai Champloo
- Samurai Deeper Kyo
- Samurai Girl
- Samurai High School
- Samurai Jack
- Samurai Pizza Cats
- Sanctuary
- Sandglass
- Sandokan
- Sanford and Son
- Sang Doo, Let's Go To School
- Santa Barbara
- Sapuri
- Terminator: The Sarah Connor Chronicles
- The Sarah Jane Adventures
- Sarah Palin's Alaska
