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Sit Down, Shut Up is an animated comedy about the lives of eight staff members at a high school in a small northeastern fishing town. Sue Sezno (Kenan Thompson) is the acting principal -- the principal is recovering from a series of escape attempts unfortunate accidents -- and a woman who frequently says "no." Next in line is vice principal Stuart Prozackian (Will Forte) who has a never ending positive and upbeat attitude, most likely due to performance-enhancing medication the other teachers secretly put him on. It's been said that those who can teach teach gym, and that saying sums up the life of Larry Slimp (Jason Bateman), who has been exiled to the gym. Larry has a crush on Miracle Grohe (Maria Bamford), the science teacher who balances science with her superficial grasp on spirituality. Rounding out the staff is Willard Deutschebog (Henry Winkler), an aging German teacher; Helen Klench (Cheri Oteri), the uptight librarian angered that her life's work in research and archiving can be outdone by a simple Google search; Andrew Sapien (Nick Kroll), the flamboyant drama teacher; Ennis Hofftard (Will Arnett), a self-obsessed body builder; and Happy (Tom Kenny), the custodian.