- 1 Richard Lewis
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Air Date: 2001-01-09
- 2 Vitamin C
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Air Date: 2001-01-10
- 3 Julia Stiles
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Air Date: 2001-01-11
- 4 William Dafoe
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Air Date: 2001-01-15
- 5 Tim Robbins
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Air Date: 2001-01-16
- 6 Sam Donaldson
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Air Date: 2001-01-17
- 7 Lynn Whitfield
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Air Date: 2001-01-18
- 8 Bill O'Reilly
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Air Date: 2001-01-22
- 9 Matthew McConaughey
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Air Date: 2001-01-23
- 10 Terry Bradshaw
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Air Date: 2001-01-24
- 11 Topher Grace
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Air Date: 2001-01-25
- 12 David Boreanaz
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Air Date: 2001-01-29
- 13 Dyan Cannon
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Air Date: 2001-01-30
- 14 James van der Beek
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Air Date: 2001-01-31
- 15 Tim Blake Nelson
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Air Date: 2001-02-01
- 16 Dave Grohl
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Air Date: 2001-02-12
- 17 Kermit the Frog
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Air Date: 2001-02-13
- 18 Jessica Alba
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Air Date: 2001-02-14
- 19 Wanda Sykes
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Air Date: 2001-02-15
- 20 Greg Germann
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Air Date: 2001-02-20
- 21 Chris Rock
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Air Date: 2001-02-21
- 22 Kelly Ripa
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Air Date: 2001-02-22
- 23 Ted Danson
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Air Date: 2001-02-26
- 24 Joe Pantoliano
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Air Date: 2001-02-27
- 25 Heather Locklear
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Air Date: 2001-02-28
- 26 Warren Christopher
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Air Date: 2001-03-01
- 27 Martin Short
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Air Date: 2001-03-05
- 28 Ed Burns
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Air Date: 2001-03-06
- 29 Carmen Electra
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Air Date: 2001-03-07
- 30 Javier Bardem
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Air Date: 2001-03-08
- 31 Chris Meloni
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Air Date: 2001-03-19
- 32 Mary Stuart Masterson
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Air Date: 2001-03-20
- 33 Jeff Varner
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Air Date: 2001-03-21
- 34 Denis Leary
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Air Date: 2001-03-22
- 35 Richard Roeper
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Air Date: 2001-03-26
- 36 Richard Lewis
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Air Date: 2001-03-27
- 37 Mark Harmon
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Air Date: 2001-03-28
- 38 Jennifer Love Hewitt
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Air Date: 2001-03-29
- 39 Lisa Ling
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Air Date: 2001-04-02
- 40 Amy Sedaris
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Air Date: 2001-04-03
- 41 D.L. Hughley
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Air Date: 2001-04-04
- 42 Steven Weber
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Air Date: 2001-04-05
- 43 Paul Reubens
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Air Date: 2001-04-09
- 44 Bob Costas
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Air Date: 2001-04-10
- 45 Damon Wayans
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Air Date: 2001-04-11
- 46 Brittany Daniel
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Air Date: 2001-04-12
- 47 Don Hewitt
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Air Date: 2001-04-23
- 48 Rachael Leigh Cook
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Air Date: 2001-04-24
- 49 Tom Green
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Air Date: 2001-04-25
- 50 Tom Cavanagh
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Air Date: 2001-04-26
- 51 Eric McCormack
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Air Date: 2001-04-30
- 52 Dominic Chianese
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Air Date: 2001-05-01
- 53 No Guest
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Air Date: 2001-05-02
- 54 Robert Patrick
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Air Date: 2001-05-03
- 55 Chris Robinson
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Air Date: 2001-05-07
- 56 James Van Der Beek
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Air Date: 2001-05-08
- 57 Richie Sambora
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Air Date: 2001-05-09
- 58 Patricia Richardson
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Air Date: 2001-05-10
- 59 Maura Tierney
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Air Date: 2001-05-14
- 60 Denise Quiñones
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Air Date: 2001-05-15
- 61 Heath Ledger
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Air Date: 2001-05-16
- 62 Jerry Springer
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Air Date: 2001-05-17
- 63 Richard Schiff
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Air Date: 2001-05-29
- 64 Bradley Whitford
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Air Date: 2001-05-30
- 65 Leah Remini
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Air Date: 2001-05-31
- 66 Jake Johannsen
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Air Date: 2001-06-04
- 67 Richard Belzer
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Air Date: 2001-06-05
- 68 Al Roker
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Air Date: 2001-06-06
- 69 Bernie Mac
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Air Date: 2001-06-07
- 70 Joe Queenan
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Air Date: 2001-06-11
- 71 Gene Simmons
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Air Date: 2001-06-12
- 72 David Duchovny
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Air Date: 2001-06-13
- 73 Jeff Greenfield
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Air Date: 2001-06-14
- 74 Martin Short
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Air Date: 2001-06-18
- 75 Michael Rapaport
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Air Date: 2001-06-19
- 76 Alec Baldwin
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Air Date: 2001-06-20
- 77 Mýa
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Air Date: 2001-06-21
- 78 Sam Robards
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Air Date: 2001-06-25
- 79 Johnny Knoxville
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Air Date: 2001-06-26
- 80 Jet Li
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Air Date: 2001-06-27
- 81 Bridget Fonda
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Air Date: 2001-06-28
- 82 Sean Hayes
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451. Sean Hayes First aired: 7/9/2001 Production Code: 6001 Tonight, actor Sean Hayes from Will & Grace.
Air Date: 2001-07-09
- 83 The Spice Girls
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452. Spice Girls First aired: 7/10/2001 Production Code: 6002 Tonight, the Spice Girls. Replay of Posh & Baby Spice Interview from (2000-10-25).
Air Date: 2001-07-10
- 84 James Woods
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James Woods
Air Date: 2001-07-11
- 85 Vince Vaughn
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Vince Vaughn
Air Date: 2001-07-12
- 86 Jon Favreau
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Jon Favreau
Air Date: 2001-07-16
- 87 Maria Bartiromo
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Maria Bartiromo
Air Date: 2001-07-17
- 88 Ed Norton
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They Might Be Giants
Air Date: 2001-07-18
- 89 Hank Azaria
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Hank Azaria
Air Date: 2001-07-19
- 90 Larry Miller
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Air Date: 2001-07-23
- 91 Paul Giametti
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Paul Giametti
Air Date: 2001-07-24
- 92 Senator Joe Lieberman
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Air Date: 2001-07-25
- 93 Senator John McCain
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Senator John McCain
Air Date: 2001-07-26
- 94 Jerri Manthey
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Air Date: 2001-07-30
- 95 Peter Krause
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Air Date: 2001-07-31
- 96 Jackie Chan
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Air Date: 2001-08-01
- 97 Janeane Garofalo
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Air Date: 2001-08-02
- 98 Andie MacDowell
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Air Date: 2001-08-06
- 99 Joe Rogan
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Air Date: 2001-08-07
- 100 Tara Reid
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Air Date: 2001-08-08
- 101 Jason Biggs
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Air Date: 2001-08-09
- 102 David Rakoff
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Air Date: 2001-08-13
- 103 John Carpenter
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Air Date: 2001-08-14
- 104 Seth Green
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Air Date: 2001-08-15
- 105 Fabio
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Air Date: 2001-08-16
- 106 Cuba Gooding Jr.
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Air Date: 2001-08-20
- 107 Griffin Dunne
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Air Date: 2001-08-21
- 108 Will Ferrell
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Air Date: 2001-08-22
- 109 Kevin Smith
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Air Date: 2001-08-23
- 110 They Might Be Giants
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Air Date: 2001-09-10
- 111 Dave Navarro
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Was scheduled guest for 2001-09-11, but show never aired
- 112 The Comeback Episode
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The Daily Show returns to the air from the New York studio in their first episode after the tragedy of September 11th, 2001.
Air Date: 2001-09-20
- 113 Frank Rich
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Air Date: 2001-09-24
- 114 Aaron Brown
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Air Date: 2001-09-25
- 115 Jeff Greenfield
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Air Date: 2001-09-26
- 116 Tenacious D
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Air Date: 2001-09-27
- 117 Kelsey Grammer
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Air Date: 2001-10-01
- 118 Jim Belushi
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Air Date: 2001-10-02
- 119 Stephen Morse
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Air Date: 2001-10-03
- 120 Kate Beckinsale
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Air Date: 2001-10-04
- 121 Owen Wilson
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Air Date: 2001-10-09
- 122 Jeremy Piven
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Air Date: 2001-10-10
- 123 John Miller
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John Miller
Air Date: 2001-10-11
- 124 Emeril Lagasse
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Air Date: 2001-10-15
- 125 Lorraine Bracco
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Tonight, actress Lorraine Bracco from The Sopranos.
Air Date: 2001-10-16
- 126 Snoop Dogg
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Air Date: 2001-10-17
- 127 Fareed Zakaria
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Air Date: 2001-10-18
- 128 Lance Bass
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Air Date: 2001-10-22
- 129 Don Dahler
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Air Date: 2001-10-23
- 130 Greta Van Susteren
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Air Date: 2001-10-24
- 131 Jeff Bridges
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Air Date: 2001-10-25
- 132 Rob Morrow
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Air Date: 2001-10-30
- 133 Richard Holbrooke
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Air Date: 2001-10-31
- 134 Kevin Spacey
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Air Date: 2001-11-01
- 135 Paul Rudd
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Tonight, actor Paul Rudd.
Air Date: 2001-11-05
- 136 P.J. O'Rourke
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Air Date: 2001-11-06
- 137 George Stephanopoulos
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Air Date: 2001-11-07
- 138 Jennifer Saunders
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Air Date: 2001-11-08
- 139 Steve Kroft
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Air Date: 2001-11-12
- 140 Anne Robinson
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Air Date: 2001-11-13
- 141 Carson Daly
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Air Date: 2001-11-14
- 142 John Stamos
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Air Date: 2001-11-15
- 143 Edward Burns
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Air Date: 2001-11-26
- 144 Star Jones
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Air Date: 2001-11-27
- 145 Jennifer Garner
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Air Date: 2001-11-28
- 146 David Halberstam
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Air Date: 2001-11-29
- 147 Nadine Strossen
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Air Date: 2001-12-03
- 148 John Edward
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Air Date: 2001-12-04
- 149 Marg Helgenberger
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Air Date: 2001-12-05
- 150 Ted Danson
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Air Date: 2001-12-06
- 151 Stephen Colbert as Al Sharpton
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Air Date: 2001-12-10
- 152 Dave Gorman
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Air Date: 2001-12-11
- 153 Janeane Garofalo
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Air Date: 2001-12-12
- 154 Tracey Ullman
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Air Date: 2001-12-13
- 155 Elijah Wood
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Air Date: 2001-12-17
- 156 Peggy Noonan
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Air Date: 2001-12-18
- 157 Gary Sinise
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Air Date: 2001-12-19
- 158 Jamie Foxx
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Air Date: 2001-12-20